Folic Acid Deficiency in Severe Hypothyroidism: A Case Report and a Review of Literature

Abstract

Introduction: Folic acid deficiency anemia and hypothyroidism are common health issues with apparent clinical presentations. While the relationship between thyroid dysfunction and dysfunction in folate metabolism has been describing, comprehensive reports on the concurrent of severe hypothyroidism and folic acid deficiency are confined. This case study aims to explain the clinical presentation, diagnostic evaluation, and management of coexistence folic acid deficiency anemia and hypothyroidism, underscoring the significance of prompt diagnosis and intervention.

Case Report: A 22-year-old woman presented with symptoms suggestive of both folic acid deficiency anemia and hypothyroidism, including palpitation, fatigue, generalized body pain, and headache. Laboratory tests revealed macrocytic anemia, elevated thyroid-stimulating hormone (TSH) levels, and decreased free thyroxine (T4) levels, prompting further assessment for dual deficiencies. Thyroid ultrasound confirmed the diagnosis of thyroiditis, confirming the clinical findings. Early initiation of folic acid supplementation and thyroid hormone therapy led to importance clinical improvement, with resolution of symptoms and normalization of hematological and thyroid profiles during follow-up.

Conclusion: Early diagnosis and management of coexistence folic acid deficiency anemia and hypothyroidism are important for enhancing patient outcomes. By improving our understanding of this complex interplay, physicians can steer better intervention strategies and enhance patient care in clinical settings.